Dorottya Kövesdi Ph.D. MTA Premium Postdoctoral Research Fellow   Email: dkovesdi(at)ttk.elte.hu

Short CV

• 2016-               MTA Premium Postdoctoral Research Fellow
• 2014-2016       Senior Research fellow at ELTE Dept. of Immunology, Prof. Gabriella Sarmay’s lab
• 2012-2014       Magyary Zoltan postdoctoral fellow at ELTE Dept. of Immunology
• 2009-2011       Magyary Zoltan postdoctoral fellow at ELTE Dept. of Immunology
• 2008-2009       Research fellow at ELTE Dept. of Immunology
• 2004-2008       Postdoctoral Research Fellow at The Babraham Institute, Cambridge, UK, The Lymphocyte Signalling and Development ISP, Dr. Martin Turner’s lab
• 2004                PhD in Immunology, Biology doctorate school,
• 1998                Msc diploma, Biology and chemistry teacher, Lorand Eotvos University, Budapest, Hungary

Research interest

• B cell development
• Developmental differences in B cell signalling
• Rheumatoid arthritis and its mouse model (CIA; collagen-induced arthritis)
• Receptor crosstalk between TLR9 and BCRs and its role in CIA
• Differentiation of marginal zone B cells

MTA Premium Postdoctoral Research project:

Regulatory role of marginal zone B cells in collagen-induced arthritis

PhD students joined to the project

Krisztina Huber (finished with PhD in 2018)

Balazs L Baratki (2017- )

Selected publications

• Csepregi JZ, Orosz A, Zajta E, Kása O, Németh T, Simon E, Fodor S, Csonka K, Barátki BL, Kövesdi D, He YW, Gácser A, Mócsai A. Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form. JOURNAL OF IMMUNOLOGY 201 : 12 pp. 3793-3803. , 11 p. (2018)
• Huber, K ; Sarmay, G ; Kovesdi, D. MZ B cells migrate in a T-bet dependent manner and might contribute to the remission of collagen-induced arthritis by the secretion of IL-10. EUROPEAN JOURNAL OF IMMUNOLOGY 46 : 9 pp. 2239-2246. , 8 p. (2016)
• Schneider Z, Jani PK, Szikora B, Végh A, Kövesdi D, Iliás A, Cervenak J, Balogh P, Kurucz I, Kacskovics I. Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen. Front Immunol. 2015 Jul 20;6:357
• Herbáth M, Szekeres Z, Kövesdi D, Papp K, Erdei A, Prechl J. Coadministration of antigen-conjugated and free CpG: Effects of in vitro and in vivo interactions in a murine model. Immunology Letters 160:(2) pp. 178-185. (2014)
• Kovesdi D, Angyal A, Huber K, Szili D, Sarmay G. T-bet is a new synergistic meeting point for the BCR and TLR9 signaling cascades. European Journal of Immunology 44:(3) pp. 887-893. (2013)
• Végh A, Farkas A, Kövesdi D, Papp K, Cervenak J, Schneider Z, Bender B, Hiripi L, László G, Prechl J, Matkó J, Kacskovics I. FcRn Overexpression in Transgenic Mice Results in Augmented APC Activity and Robust Immune Response with Increased Diversity of Induced Antibodies. PLOS ONE 7:(4) p. e36286. (2012)
• Szarka E, Neer Z, Balogh P, Adori M, Angyal A, Prechl J, Kiss E, Kovesdi D, Sarmay G. Exacerbation of collagen induced arthritis by Fcgamma receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production. BIOLOGICS: TARGETS & THERAPY 6: pp. 101-115. (2012)
• Kövesdi D, Bell SE, Turner M. The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K. Self Nonself. 2010 Apr;1(2):144-153.
• Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LM, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol. 2010 Oct 1;185(7):4042-52.
• Henley T, Kovesdi D, Turner M. B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol.2008 Dec;38(12):3543-8
• Vigorito E, Kovesdi D, Turner M. Cell Signal. Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma. 2006. 18(9):1455-60.
• Hebeis B, Vigorito E, Kovesdi D, Turner M. Vav proteins are required for B-lymphocyte responses to LPS. Blood. 2005. 106(2):635-40.
• Kövesdi D, Paszty K, Enyedi A, Kiss E, Matko J, Ludanyi K, Rajnavolgyi E, Sarmay G. Antigen receptor-mediated signaling pathways in transitional immature B cells. Cell. Signal. 2004. 16:881-9.
• Sarmay G, Koncz G, Bodor Cs, Kövesdi D, Gati R. Signaling pathways leading to apoptosis or survival in immature and mature B cells. Ann. N. Y. Acad. Sci. 2002. 973: 181-185.
• Koncz G, Bodor Cs, Kövesdi D, Gati R, Sarmay G. BCR mediated signal transduction in immature and mature B cells. Immunol. Lett. 2002. 82: 41-9.
• Kövesdi D, Koncz G, Ivanyi-Nagy R, Caspi Y, Ishiai M, Kurosaki T, Gergely J, Haimovich J, Sarmay G. Developmental differences in B cell receptor-induced signal transduction. Cell. Signal. 2002. 14: 563-72.